Image via Wikimedia Commons.
St. Denis Medical returns tonight, Monday, 2 November 2026, with the premiere of its third season on NBC. The mockumentary medical comedy, created by Justin Spitzer and Eric Ledgin, will air at 8 p.m. ET, with the season opener followed by the return of the sitcom Reggie Dinkins at 8:30 p.m. ET.
Season 3 picks up at St. Denis Medical in Portland, Oregon, where the staff of the underfunded, understaffed hospital continue to juggle patient care, hospital politics and their own tangled personal lives. The season premiere, titled "He Ain't Noah Wyle", sets up a new chapter for the team after the events of the second season, which ended with a cliffhanger for several of the show's central characters.
Tonight's episode, "He Ain't Noah Wyle", is the first episode of the third season. It introduces a new dynamic at the hospital, with the arrival of a new doctor shaking up the established order. The episode also features a guest appearance by Damon Wayans, who joins the cast for a special role in the season opener.
In season 3, the main cast returns, including Wendi McLendon-Covey as Joyce, the hospital's executive director, David Alan Grier as Dr Ron, Allison Tolman as Dr Alex, Josh Lawson as Dr Bruce, Mekki Leeper as Matt, Kahyun Kim as Serena, and Kaliko Kauahi as Val. The show's ensemble cast has been praised for its chemistry, and season 3 is expected to build on the show's growing popularity.
| St. Denis Medical Season 3 premiere | Details |
|---|---|
| Premiere date | Monday, 2 November 2026 |
| Time | 8 p.m. ET on NBC |
| Episode 1 | "He Ain't Noah Wyle" (Season 3, Episode 1) |
| Followed by | Reggie Dinkins, Season 2, at 8:30 p.m. ET |
| Streaming | Peacock the next day; Season 2 on Netflix in the US from 3 November 2026 |
Season 3 arrives with real momentum: the show climbed from a 79% Rotten Tomatoes score in its debut season to a perfect 100% for season 2, and it also grew its audience — rising from 4.04 million viewers to 5.27 million viewers for the second-season finale.
How to watch is straightforward: tune in to NBC at 8 p.m. ET tonight, or stream the episode on Peacock the next day. Season 2 will also be available on Netflix in the United States from November 3.
For NBC's other big premieres this week, see our coverage of Saturday Night Live's Halloween episode and The Gilded Age season 4 premiere.
Read More: The Gilded Age Season 4 Premiere: Release Date, Time, Cast and Episode Schedule
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